On February 25, 2022, the US Environmental Protection Agency (EPA) rejected all opinions against abolishing the current maximum residue limit of Chlorpyrifos in food, which indicates that EPA will completely ban all chlorpyrifos related food uses.

    In addition, the EPA has sent a letter to the registrant of chlorpyrifos products with food use. The registrant can choose to remove the food related use from the product label or voluntarily cancel the products with food use only. The EPA will issue a subsequent notice to forcibly delete the food use or cancel the registration for the products that have not been deleted and the products that have only food use that have not been voluntarily cancelled.

    Chlorpyrifos is an organophosphorus insecticide used in crops including soybeans, fruit and nut trees, broccoli and cauliflower.

    However, because chlorpyrifos can inhibit acetylcholinesterase (AChE) in the body and lead to neurotoxicity, the use of chlorpyrifos has been declining. Many other countries, including the European Union and Canada, as well as some states, including California, Hawaii and New York, have also taken actions to limit the use of Chlorpyrifos in food. Therefore, it has undergone many reviews since its registration in 1965.